Term	Overlap	P-value	Adjusted P-value	Old P-value	Old Adjusted P-value	Odds Ratio	Combined Score	Genes
hormone activity (GO:0005179)	16/84	2.4515901258123943E-10	2.821780234810066E-7	0	0	7.619047619047619	168.60277398071983	CGB7;LHB;CGB3;CCK;CGB2;CSHL1;INHBA;CGB1;GH2;APELA;VGF;LEP;CRH;PPY;CGA;INHA
cytokine receptor binding (GO:0005126)	13/138	4.3848745426192267E-5	0.02523495299277365	0	0	3.7681159420289854	37.812155899050055	GDF15;LIFR;IL27;INHBA;CSHL1;GDF6;BMP7;PGF;BMP5;GH2;CCRL2;IL36RN;INHA
growth factor activity (GO:0008083)	9/70	5.961143017273056E-5	0.022870918709604292	0	0	5.142857142857142	50.02798227870353	NTF4;GH2;ENDOU;HGF;CSHL1;INHBA;INHA;AREG;PGF
core promoter proximal region sequence-specific DNA binding (GO:0000987)	17/279	6.987292828887996E-4	0.20105935115125206	0	0	2.4372759856630823	17.709849764413377	TFAP2A;NFE2;GCM1;DLX4;GATA3;MEOX2;GRHL1;TBX5;ASCL2;POU2F3;ETV4;NR6A1;MYCN;ZFP42;HAND1;FOSB;ATF3
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0000982)	17/281	7.565766996226317E-4	0.1741639562531298	0	0	2.4199288256227756	17.391318565246035	TFAP2A;GCM1;DLX4;TCF21;HMGA2;GATA3;MEOX2;GRHL1;ASCL2;POU2F3;ETV4;MYCN;ZFP42;HAND1;FOSB;ATF3;ZNF750
transforming growth factor beta receptor binding (GO:0005160)	6/45	8.437696124754264E-4	0.16186313732653596	0	0	5.333333333333333	37.747365715372595	GDF15;INHBA;GDF6;INHA;BMP7;BMP5
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228)	17/285	8.846442698641093E-4	0.14546079351622712	0	0	2.3859649122807016	16.774108649572057	TFAP2A;GCM1;CEBPA;GATA5;TCF21;HMGA2;GATA4;GRHL3;GATA3;FOXO4;MEOX2;GRHL1;POU2F3;ETV4;MYCN;ATF3;ZNF750
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0033764)	4/21	0.0016471077800394765	0.2369776318531797	0	0	7.619047619047619	48.828452493024685	HSD11B2;DHRS9;HSD17B1;HSD3B1
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978)	15/263	0.0026793541512887577	0.3426596253481511	0	0	2.2813688212927756	13.510675669566877	TFAP2A;GCM1;DLX4;MEOX2;GRHL1;TBX5;ASCL2;POU2F3;ETV4;NR6A1;MYCN;ZFP42;HAND1;FOSB;ATF3
transcription coactivator activity (GO:0003713)	16/292	0.0029261121679012747	0.3367955105254367	0	0	2.191780821917808	12.787026065149542	TFAP2A;NFE2;TFAP2B;CEBPA;WNT3A;GATA4;GATA3;MED12L;CCNE1;HAND1;TBX20;NFE2L3;PPARG;PITX2;VGLL1;BRDT
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001078)	8/98	0.003180617651819894	0.3328082652040634	0	0	3.265306122448979	18.777730190753434	TFAP2A;DLX4;ZFP42;HAND1;HMGA2;TCF21;GATA3;ASCL2
neutral amino acid transmembrane transporter activity (GO:0015175)	4/25	0.0032171757921806987	0.30858077806666534	0	0	6.3999999999999995	36.731208879756906	SLC7A5;SLC6A19;SLC43A2;SLC38A3
tropomyosin binding (GO:0005523)	3/14	0.004603033511907417	0.4075455055542644	0	0	8.571428571428571	46.12319771763762	TNNT1;TNNT2;TNNT3
heparan sulfate sulfotransferase activity (GO:0034483)	3/14	0.004603033511907417	0.37843511230038834	0	0	8.571428571428571	46.12319771763762	HS3ST3B1;HS3ST3A1;HS6ST2
sequence-specific DNA binding (GO:0043565)	19/395	0.00524041109269656	0.4021142111795827	0	0	1.9240506329113922	10.103873548102625	TFAP2A;NFE2;IRX2;TFAP2B;DLX4;MSX2;GATA4;GRHL3;FOXO4;TBX5;MEOX2;GRHL1;POU2F3;MMP12;NR6A1;ZFP42;MAEL;PPARG;TP63
calcium ion binding (GO:0005509)	15/285	0.005627829986876263	0.40485201968091117	0	0	2.1052631578947367	10.90532915501145	TNNC1;TCHH;GUCA1A;LRP2;SYT8;SYT7;MMP12;TNNT1;TNNT2;TNNT3;MAN1C1;ANXA8;CASQ1;S100A9;CD320
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)	21/461	0.006334872956820328	0.4289081631353057	0	0	1.822125813449024	9.223027844791735	TFAP2A;GCM1;TFAP2B;DLX4;GATA5;GATA4;GATA3;TBX5;MEOX2;GRHL1;ASCL2;POU2F3;ETV4;NR6A1;MYCN;ZFP42;HAND1;TBX20;FOSB;PPARG;ATF3
sequence-specific double-stranded DNA binding (GO:1990837)	8/113	0.007493428841261588	0.4791631442384493	0	0	2.831858407079646	13.858347035712622	TFAP2A;NFE2;NFE2L3;HMGA2;PPARG;GATA3;PITX2;ATF3
apolipoprotein receptor binding (GO:0034190)	2/6	0.0087524127649488	0.5302119522345299	0	0	13.333333333333332	63.17901162743442	APOA2;ABCA12
azole transmembrane transporter activity (GO:1901474)	2/6	0.0087524127649488	0.5037013546228034	0	0	13.333333333333332	63.17901162743442	SLC19A3;SLC38A3
dopamine transmembrane transporter activity (GO:0005329)	2/6	0.0087524127649488	0.47971557583124136	0	0	13.333333333333332	63.17901162743442	SLC6A2;SLC6A4
very long-chain fatty acid-CoA ligase activity (GO:0031957)	2/6	0.0087524127649488	0.45791032238436674	0	0	13.333333333333332	63.17901162743442	SLC27A2;ACSBG2
cytokine receptor activity (GO:0004896)	6/74	0.010475384097409076	0.5242246563529499	0	0	3.2432432432432434	14.78506101352144	CNTFR;IL1RAPL2;EBI3;LIFR;CSF2RB;IL22RA2
MAP kinase tyrosine/serine/threonine phosphatase activity (GO:0017017)	2/7	0.012051662882171474	0.5779776657241403	0	0	11.428571428571427	50.49774434338215	DUSP5;DUSP9
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity (GO:0008467)	2/7	0.012051662882171474	0.5548585590951747	0	0	11.428571428571427	50.49774434338215	HS3ST3B1;HS3ST3A1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001077)	10/176	0.013298234587115149	0.5887026157603668	0	0	2.2727272727272725	9.818463614490371	TFAP2A;GCM1;MYCN;HMGA2;TCF21;MEOX2;GRHL1;POU2F3;ETV4;ZNF750
amino acid transmembrane transporter activity (GO:0015171)	5/57	0.013793849088617314	0.5880266778147603	0	0	3.508771929824561	15.029938611919315	SLC7A5;SLC6A19;SLC43A2;SLC6A15;SLC38A3
transcription regulatory region DNA binding (GO:0044212)	17/375	0.013812008457569504	0.567772204809375	0	0	1.8133333333333335	7.765086621977036	TFAP2A;NFE2;CEBPA;MSX2;GATA5;TCF21;HMGA2;GATA4;GATA3;GRHL1;ASCL2;MMP12;HAND1;NFE2L3;PPARG;PITX2;ATF3
growth hormone receptor binding (GO:0005131)	2/8	0.01580491452517871	0.627291607533817	0	0	10.0	41.47434341416576	GH2;CSHL1
monoamine transmembrane transporter activity (GO:0008504)	2/8	0.01580491452517871	0.6063818872826897	0	0	10.0	41.47434341416576	SLC6A2;SLC6A4
cytokine activity (GO:0005125)	9/156	0.016753735091771253	0.6220499706654423	0	0	2.3076923076923075	9.436463203883656	GDF15;FAM3B;WNT7A;IL36RN;INHBA;GDF6;INHA;BMP7;BMP5
core promoter proximal region DNA binding (GO:0001159)	3/22	0.01679971420817187	0.6042647204251819	0	0	5.454545454545454	22.289418568014327	TFAP2A;NFE2;GATA3
RNA polymerase II transcription coactivator activity (GO:0001105)	4/40	0.017333054887491272	0.6045559447121955	0	0	4.0	16.220559653524184	TFAP2B;TBX20;PITX2;MED12L
peptidase activity, acting on L-amino acid peptides (GO:0070011)	10/186	0.018866997870101977	0.6387033690731582	0	0	2.150537634408602	8.538367801382353	MMP12;ENDOU;PRSS41;USP9Y;ADAM12;HTRA4;PRSS8;TMPRSS11E;PRSS12;PAPPA2
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001227)	9/160	0.019423829055634948	0.6387664926581665	0	0	2.25	8.867822995848483	TFAP2A;IRX2;DLX4;ZFP42;HAND1;HMGA2;TCF21;GATA3;ASCL2
MAP kinase phosphatase activity (GO:0033549)	2/9	0.019987498286726836	0.6390447368895164	0	0	8.888888888888888	34.779095880349324	DUSP5;DUSP9
carboxylic acid transmembrane transporter activity (GO:0046943)	5/65	0.023168811652081647	0.7207378976093507	0	0	3.076923076923077	11.584456092514266	SLC7A5;SLC6A19;SLC43A2;SLC6A15;SLC38A3
anion:cation symporter activity (GO:0015296)	4/44	0.02382609847412197	0.721679982729326	0	0	3.6363636363636362	13.58899536203803	SLC13A4;SLC6A15;SLC6A11;SLC4A4
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	2/10	0.02457569018526242	0.7252979334163345	0	0	8.0	29.64798022792225	PHOSPHO1;ALPL
long-chain fatty acid-CoA ligase activity (GO:0004467)	2/10	0.02457569018526242	0.7071654850809261	0	0	8.0	29.64798022792225	SLC27A2;ACSBG2
co-SMAD binding (GO:0070410)	2/10	0.02457569018526242	0.6899175464204158	0	0	8.0	29.64798022792225	USP9Y;GATA4
regulatory region DNA binding (GO:0000975)	11/225	0.02652924462368878	0.7270276324253759	0	0	1.9555555555555555	7.097703719374876	TFAP2A;CEBPA;MSX2;HAND1;GATA5;HMGA2;GATA4;PPARG;GATA3;GRHL1;ATF3
neuropeptide hormone activity (GO:0005184)	3/27	0.029117852235481113	0.7794104168148549	0	0	4.444444444444444	15.717350284548534	PPY;CRH;CCK
gap junction channel activity (GO:0005243)	2/11	0.02954667996708659	0.7729142873208332	0	0	7.2727272727272725	25.612973778194785	GJA5;GJB7
complement receptor activity (GO:0004875)	2/11	0.02954667996708659	0.7557384142692591	0	0	7.2727272727272725	25.612973778194785	GPR32P1;GPR32
phospholipase activity (GO:0004620)	5/70	0.03071766872573008	0.7686094935503331	0	0	2.8571428571428568	9.951192175476	PLA2G2F;GDPD1;PLA2G5;CLC;NOTUM
transcription regulatory region sequence-specific DNA binding (GO:0000976)	13/293	0.03357942014954647	0.8223385657899572	0	0	1.7747440273037542	6.023200633144686	TFAP2A;NFE2;TFAP2B;GATA5;GATA4;GATA3;ASCL2;TBX20;NFE2L3;PPARG;PITX2;ATF3;ZNF750
RNA polymerase II transcription factor binding (GO:0001085)	7/122	0.0336650616831555	0.8072601249439996	0	0	2.2950819672131146	7.783299368216559	ZFP42;TBX20;GATA5;GATA4;GATA3;PITX2;PITX1
BMP receptor binding (GO:0070700)	2/12	0.03487854042134841	0.8192897964280004	0	0	6.666666666666666	22.372556843567576	BMP7;BMP5
wide pore channel activity (GO:0022829)	2/12	0.03487854042134841	0.8029040004994404	0	0	6.666666666666666	22.372556843567576	GJA5;GJB7
sodium:amino acid symporter activity (GO:0005283)	2/12	0.03487854042134841	0.7871607848033729	0	0	6.666666666666666	22.372556843567576	SLC6A15;SLC6A11
oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor (GO:0050664)	2/12	0.03487854042134841	0.7720230774033081	0	0	6.666666666666666	22.372556843567576	NCF1;KMO
core promoter sequence-specific DNA binding (GO:0001046)	5/74	0.037751290429200716	0.8198440619624533	0	0	2.7027027027027026	8.856042217071249	TFAP2A;TFAP2B;PPARG;GATA3;ZNF750
WW domain binding (GO:0050699)	3/30	0.038268755933891604	0.8156914459242451	0	0	4.0	13.052485950718438	NFE2;SCNN1B;TP63
transcriptional activator activity, RNA polymerase II transcription factor binding (GO:0001190)	4/51	0.03832523471749994	0.8020426392698624	0	0	3.1372549019607843	10.232617191675	TFAP2B;TBX20;PITX2;MED12L
collagen binding (GO:0005518)	4/53	0.04321791047116662	0.8882824098627281	0	0	3.0188679245283017	9.48377441633977	MMP12;PCOLCE2;ADGRG6;COCH
protein tyrosine/serine/threonine phosphatase activity (GO:0008138)	3/35	0.056354567885378765	1.0	0	0	3.4285714285714284	9.860886785287258	DUSP5;DUSP9;DUSP13
E-box binding (GO:0070888)	3/35	0.056354567885378765	1.0	0	0	3.4285714285714284	9.860886785287258	TCF21;GATA3;ASCL2
transmembrane receptor protein serine/threonine kinase binding (GO:0070696)	2/16	0.05940541077305161	1.0	0	0	5.0	14.116849831533036	BMP7;BMP5
ion transmembrane transporter activity (GO:0015075)	3/36	0.06037988610364689	1.0	0	0	3.333333333333333	9.356997470103483	TRPV6;CHRNE;SLC4A4
steroid hydroxylase activity (GO:0008395)	3/36	0.06037988610364689	1.0	0	0	3.333333333333333	9.356997470103483	CYP2W1;CYP11A1;CYP19A1
cholesterol transporter activity (GO:0017127)	2/17	0.0662415915707929	1.0	0	0	4.705882352941176	12.773867020503221	APOA2;ABCG2
metalloaminopeptidase activity (GO:0070006)	2/17	0.0662415915707929	1.0	0	0	4.705882352941176	12.773867020503221	LVRN;MMP15
RNA polymerase II regulatory region DNA binding (GO:0001012)	9/202	0.06790070741903172	1.0	0	0	1.782178217821782	4.79354048185423	TFAP2A;TFAP2B;TBX20;GATA5;GATA4;PPARG;GATA3;ASCL2;ATF3
potassium ion transmembrane transporter activity (GO:0015079)	3/39	0.07322950908508677	1.0	0	0	3.076923076923077	8.04355941437563	KCNG1;KCNF1;KCNN4
fatty acid ligase activity (GO:0015645)	2/18	0.07332402120449992	1.0	0	0	4.444444444444444	11.612742279715478	SLC27A2;ACSBG2
hyaluronic acid binding (GO:0005540)	2/18	0.07332402120449992	1.0	0	0	4.444444444444444	11.612742279715478	ACAN;HAPLN1
G-protein coupled receptor activity (GO:0004930)	11/268	0.07465221893284832	1.0	0	0	1.6417910447761193	4.260308259773786	GPR32P1;HCAR2;P2RY6;ADGRB2;GPR78;FRZB;MTNR1B;GPR32;ADGRG6;KISS1R;CCR7
lysophospholipase activity (GO:0004622)	2/19	0.08063617099611983	1.0	0	0	4.2105263157894735	10.601296667256518	GDPD1;CLC
hormone receptor binding (GO:0051427)	3/41	0.08241355278955437	1.0	0	0	2.9268292682926824	7.305381599970589	GH2;LEP;CSHL1
metal ion binding (GO:0046872)	16/443	0.09153775635930103	1.0	0	0	1.4446952595936793	3.454271789082668	TNNC1;TCHH;GUCA1A;LRP2;SYT8;SYT7;MMP12;TNNT1;TNNT2;TNNT3;MAN1C1;ANXA8;S100P;CASQ1;S100A9;CD320
androgen receptor binding (GO:0050681)	3/43	0.0920646511043347	1.0	0	0	2.7906976744186043	6.656551309777228	KDM5D;CCNE1;TCF21
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances (GO:0016820)	3/43	0.0920646511043347	1.0	0	0	2.7906976744186043	6.656551309777228	ABCC2;ABCA12;ABCG2
activating transcription factor binding (GO:0033613)	4/69	0.09414564393963108	1.0	0	0	2.318840579710145	5.479216909417726	TBX20;PPARG;GATA4;PITX2
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (GO:0016712)	2/21	0.09588684119947874	1.0	0	0	3.8095238095238093	8.931758172484527	CYP2W1;CYP19A1
core promoter binding (GO:0001047)	5/98	0.09918802730486051	1.0	0	0	2.0408163265306123	4.71579176421747	MMP12;HMGA2;PPARG;GATA3;ZNF750
mRNA 5'-UTR binding (GO:0048027)	2/22	0.10379556080326813	1.0	0	0	3.6363636363636362	8.237571185428129	IGF2BP1;IGF2BP3
bHLH transcription factor binding (GO:0043425)	2/22	0.10379556080326813	1.0	0	0	3.6363636363636362	8.237571185428129	HAND1;TCF21
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (GO:0016702)	2/22	0.10379556080326813	1.0	0	0	3.6363636363636362	8.237571185428129	CDO1;ALOXE3
ATPase activity, coupled to transmembrane movement of substances (GO:0042626)	3/46	0.10736313441562158	1.0	0	0	2.6086956521739126	5.821404549935052	ABCC2;ABCA12;ABCG2
P-P-bond-hydrolysis-driven transmembrane transporter activity (GO:0015405)	3/46	0.10736313441562158	1.0	0	0	2.6086956521739126	5.821404549935052	ABCC2;ABCA12;ABCG2
acetylcholine receptor activity (GO:0015464)	2/23	0.11187435504137663	1.0	0	0	3.4782608695652173	7.618709103989623	CHRM2;CHRNE
calcium-dependent phospholipid binding (GO:0005544)	3/48	0.11807273003133849	1.0	0	0	2.5	5.341136220470389	ANXA8;SYT8;SYT7
carboxylic ester hydrolase activity (GO:0052689)	5/104	0.11952734733413012	1.0	0	0	1.9230769230769231	4.085019395784471	PLA2G2F;GDPD1;PLA2G5;CLC;NOTUM
phosphatase activity (GO:0016791)	5/105	0.12309486929886125	1.0	0	0	1.9047619047619047	3.99009509674713	DUSP5;PHOSPHO1;DUSP9;ALPPL2;DUSP13
steroid hormone receptor binding (GO:0035258)	4/77	0.12685161688191973	1.0	0	0	2.0779220779220777	4.290363109838066	KDM5D;CCNE1;TCF21;LRP2
ammonium transmembrane transporter activity (GO:0008519)	2/25	0.12848911332067864	1.0	0	0	3.1999999999999997	6.566115518322446	SLC44A5;SLC6A4
cysteine-type endopeptidase inhibitor activity involved in apoptotic process (GO:0043027)	2/25	0.12848911332067864	1.0	0	0	3.1999999999999997	6.566115518322446	TFAP2B;BIRC7
phosphatidylinositol-3,4-bisphosphate binding (GO:0043325)	2/25	0.12848911332067864	1.0	0	0	3.1999999999999997	6.566115518322446	NCF1;ANXA8
L-amino acid transmembrane transporter activity (GO:0015179)	3/50	0.12916025190606503	1.0	0	0	2.4	4.912083318606716	SLC7A5;SLC43A2;SLC38A3
MHC class II protein binding (GO:0042289)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	COL2A1
clathrin light chain binding (GO:0032051)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	NSG1
leukotriene receptor activity (GO:0004974)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	KISS1R
G-protein coupled neurotransmitter receptor activity (GO:0099528)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	CHRM2
cysteinyl leukotriene receptor activity (GO:0001631)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	KISS1R
G-protein coupled acetylcholine receptor activity (GO:0016907)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	CHRM2
ceramidase activity (GO:0017040)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	ACER2
phosphatidylcholine-sterol O-acyltransferase activator activity (GO:0060228)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	APOA2
NAD(P)H oxidase activity (GO:0016174)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	KMO
T cell receptor binding (GO:0042608)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	EPS8L1
LBD domain binding (GO:0050693)	1/6	0.14094786294456849	1.0	0	0	6.666666666666666	13.062434822233206	PPARG
RNA polymerase II core promoter sequence-specific DNA binding (GO:0000979)	2/28	0.15436955442437558	1.0	0	0	2.8571428571428568	5.338302420588211	TFAP2A;TFAP2B
O-acetyltransferase activity (GO:0016413)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	CHAT
AT DNA binding (GO:0003680)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	HMGA2
superoxide-generating NADPH oxidase activity (GO:0016175)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	NCF1
choline transmembrane transporter activity (GO:0015220)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	SLC44A5
estradiol 17-beta-dehydrogenase activity (GO:0004303)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	HSD17B1
cAMP response element binding (GO:0035497)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	HMGA2
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity (GO:0003836)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	ST3GAL4
alanine transmembrane transporter activity (GO:0022858)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	SLC38A3
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen (GO:0016713)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	CYP11A1
fatty acid transporter activity (GO:0015245)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	SLC27A6
L-proline transmembrane transporter activity (GO:0015193)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	SLC6A15
myosin heavy chain binding (GO:0032036)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	MYL4
protein binding involved in heterotypic cell-cell adhesion (GO:0086080)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	DSC2
acetylcholine receptor binding (GO:0033130)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	PSCA
vascular endothelial growth factor-activated receptor activity (GO:0005021)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	FLT1
cation:sugar symporter activity (GO:0005402)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	SLC2A12
L-alanine transmembrane transporter activity (GO:0015180)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	SLC38A3
NMDA glutamate receptor activity (GO:0004972)	1/7	0.16243058031155067	1.0	0	0	5.7142857142857135	10.385740380401181	GRIN2D
sterol transporter activity (GO:0015248)	2/29	0.16320629383915272	1.0	0	0	2.758620689655172	5.000662819323756	APOA2;ABCG2
RNA polymerase II transcription cofactor activity (GO:0001104)	4/85	0.16359856361460354	1.0	0	0	1.8823529411764706	3.4076981359319904	TFAP2B;TBX20;PITX2;MED12L
serine-type endopeptidase inhibitor activity (GO:0004867)	3/57	0.1705587717216263	1.0	0	0	2.1052631578947367	3.723527030473866	SERPINB2;SERPINE2;SERPINB7
phosphoric ester hydrolase activity (GO:0042578)	3/57	0.1705587717216263	1.0	0	0	2.1052631578947367	3.723527030473866	DUSP5;PHOSPHO1;DUSP13
ATPase activity, coupled to movement of substances (GO:0043492)	3/57	0.1705587717216263	1.0	0	0	2.1052631578947367	3.723527030473866	ABCC2;ABCA12;ABCG2
delayed rectifier potassium channel activity (GO:0005251)	2/30	0.17213040735200277	1.0	0	0	2.6666666666666665	4.692007752438898	KCNG1;KCNA7
phospholipase A2 activity (GO:0004623)	2/31	0.18113203111493761	1.0	0	0	2.5806451612903225	4.40910725152166	PLA2G2F;PLA2G5
glutathione transferase activity (GO:0004364)	2/31	0.18113203111493761	1.0	0	0	2.5806451612903225	4.40910725152166	GSTA3;PTGES
G-protein coupled nucleotide receptor activity (GO:0001608)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	GPR87
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity (GO:0004571)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	MAN1C1
C-C chemokine binding (GO:0019957)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	CCR7
neurotrophin TRK receptor binding (GO:0005167)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	NTF4
phosphofructokinase activity (GO:0008443)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	PFKFB4
sodium:bicarbonate symporter activity (GO:0008510)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	SLC4A4
G-protein coupled purinergic nucleotide receptor activity (GO:0045028)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	GPR87
activin receptor binding (GO:0070697)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	INHBA
epinephrine binding (GO:0051379)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	ADRB1
histone demethylase activity (H3-K4 specific) (GO:0032453)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	KDM5D
alcohol dehydrogenase (NAD) activity (GO:0004022)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	DHRS9
amide transmembrane transporter activity (GO:0042887)	1/8	0.18337711757031785	1.0	0	0	5.0	8.481052474133024	SLC38A3
actin binding (GO:0003779)	9/255	0.19017510175007976	1.0	0	0	1.4117647058823528	2.3432612372681985	MYL4;SPTA1;TNNC1;TNNT2;TNNT3;TNNI2;EPS8L1;ANXA8;SLC6A4
serine-type peptidase activity (GO:0008236)	8/221	0.19022775572416975	1.0	0	0	1.4479638009049773	2.402944015012941	MMP12;ENDOU;PRSS41;COLEC10;PRSS8;RHBDL3;TMPRSS11E;PRSS12
ligand-gated cation channel activity (GO:0099094)	3/61	0.19571013951815233	1.0	0	0	1.9672131147540983	3.2087618250165857	SCNN1B;CHRNE;GRIN2D
hydrogen-exporting ATPase activity, phosphorylative mechanism (GO:0008553)	1/9	0.20380083047636524	1.0	0	0	4.444444444444444	7.069387036640817	ATP6V1C2
RAGE receptor binding (GO:0050786)	1/9	0.20380083047636524	1.0	0	0	4.444444444444444	7.069387036640817	S100A9
superoxide-generating NADPH oxidase activator activity (GO:0016176)	1/9	0.20380083047636524	1.0	0	0	4.444444444444444	7.069387036640817	NCF1
ligand-gated sodium channel activity (GO:0015280)	1/9	0.20380083047636524	1.0	0	0	4.444444444444444	7.069387036640817	SCNN1B
retinoid X receptor binding (GO:0046965)	1/9	0.20380083047636524	1.0	0	0	4.444444444444444	7.069387036640817	PPARG
Toll-like receptor binding (GO:0035325)	1/9	0.20380083047636524	1.0	0	0	4.444444444444444	7.069387036640817	S100A9
D-glucose transmembrane transporter activity (GO:0055056)	1/9	0.20380083047636524	1.0	0	0	4.444444444444444	7.069387036640817	SLC2A12
cAMP-dependent protein kinase inhibitor activity (GO:0004862)	1/9	0.20380083047636524	1.0	0	0	4.444444444444444	7.069387036640817	PKIB
anion transmembrane transporter activity (GO:0008509)	3/63	0.20860938631238252	1.0	0	0	1.9047619047619047	2.985317601379297	ABCC2;SLC4A4;SLC22A11
ATPase activity, coupled (GO:0042623)	4/95	0.21407627612000896	1.0	0	0	1.6842105263157894	2.5960806686302367	TNNT1;TNNT2;TNNT3;FIGN
actin filament binding (GO:0051015)	5/128	0.2170847599208247	1.0	0	0	1.5625	2.3866678171750295	MYL4;SPTA1;TNNC1;ANXA8;SLC6A4
aminopeptidase activity (GO:0004177)	2/35	0.21773131350006625	1.0	0	0	2.2857142857142856	3.484556533108	LVRN;MMP15
carboxylic acid binding (GO:0031406)	2/35	0.21773131350006625	1.0	0	0	2.2857142857142856	3.484556533108	ACAN;HAPLN1
enhancer sequence-specific DNA binding (GO:0001158)	3/65	0.2216910070831208	1.0	0	0	1.8461538461538463	2.7811767260910543	TFAP2B;ZFP42;MEOX2
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding (GO:0003705)	3/65	0.2216910070831208	1.0	0	0	1.8461538461538463	2.7811767260910543	CEBPA;MEOX2;VGLL1
G-protein coupled peptide receptor activity (GO:0008528)	3/65	0.2216910070831208	1.0	0	0	1.8461538461538463	2.7811767260910543	GPR32P1;GPR32;KISS1R
Lys48-specific deubiquitinase activity (GO:1990380)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	USP27X
prostaglandin receptor activity (GO:0004955)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	PPARG
mannosyl-oligosaccharide mannosidase activity (GO:0015924)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	MAN1C1
protein kinase C activity (GO:0004697)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	PRKCZ
salt transmembrane transporter activity (GO:1901702)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	SLC22A11
activin binding (GO:0048185)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	FSTL3
sugar:proton symporter activity (GO:0005351)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	SLC2A12
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines (GO:0016813)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	PADI1
vascular endothelial growth factor receptor binding (GO:0005172)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	PGF
urate transmembrane transporter activity (GO:0015143)	1/10	0.22371474296156477	1.0	0	0	4.0	5.989534030397172	SLC22A11
metalloendopeptidase activity (GO:0004222)	3/66	0.22829261173331122	1.0	0	0	1.8181818181818181	2.685685614666917	MMP12;MMP15;PAPPA2
DNA binding (GO:0003677)	26/894	0.23974667290770416	1.0	0	0	1.16331096196868	1.661408658122158	CEBPA;GCM1;DLX4;GATA4;GATA3;FOXO4;MEOX2;MAEL;TP63;TFAP2A;NFE2;IRX2;TFAP2B;MSX2;HMGA2;GRHL3;TBX5;GRHL1;TBX4;POU2F3;MMP12;NR6A1;MYCN;ZFP42;FOSB;PPARG
sodium:potassium-exchanging ATPase activity (GO:0005391)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	ATP1A4
potassium-transporting ATPase activity (GO:0008556)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	ATP1A4
peptide hormone receptor binding (GO:0051428)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	LEP
intramolecular oxidoreductase activity, transposing C=C bonds (GO:0016863)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	HSD3B1
platelet-derived growth factor binding (GO:0048407)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	COL2A1
microtubule-severing ATPase activity (GO:0008568)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	FIGN
Lys63-specific deubiquitinase activity (GO:0061578)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	USP27X
lipase inhibitor activity (GO:0055102)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	APOA2
caspase binding (GO:0089720)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	CARD17
intramolecular transferase activity, phosphotransferases (GO:0016868)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	BPGM
neuropeptide receptor binding (GO:0071855)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	APELA
mannose binding (GO:0005537)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	COLEC10
intermediate filament binding (GO:0019215)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	KRT14
MAP kinase kinase kinase kinase activity (GO:0008349)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	NRK
peptide alpha-N-acetyltransferase activity (GO:0004596)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	NAA11
2 iron, 2 sulfur cluster binding (GO:0051537)	1/11	0.2431315551769016	1.0	0	0	3.6363636363636362	5.142373101111616	FDX1
G-protein coupled receptor binding (GO:0001664)	5/134	0.24460997895437925	1.0	0	0	1.4925373134328357	2.10162725302657	WNT3A;CCRL2;PPY;WNT7A;ADM
frizzled binding (GO:0005109)	2/38	0.24557301167059375	1.0	0	0	2.1052631578947367	2.956128370698781	WNT3A;WNT7A
potassium channel activity (GO:0005267)	4/101	0.24619177364498787	1.0	0	0	1.584158415841584	2.220426897571902	KCNG1;KCNF1;KCNN4;KCNA7
metallopeptidase activity (GO:0008237)	4/103	0.2571271620434609	1.0	0	0	1.553398058252427	2.1098012000212023	MMP12;MMP15;ADAM12;PAPPA2
arylsulfatase activity (GO:0004065)	1/12	0.26206365162305645	1.0	0	0	3.333333333333333	4.463892865337529	ARSI
ATPase-coupled anion transmembrane transporter activity (GO:0043225)	1/12	0.26206365162305645	1.0	0	0	3.333333333333333	4.463892865337529	ABCC2
C2H2 zinc finger domain binding (GO:0070742)	1/12	0.26206365162305645	1.0	0	0	3.333333333333333	4.463892865337529	HMGA2
DNA-(apurinic or apyrimidinic site) lyase activity (GO:0003906)	1/12	0.26206365162305645	1.0	0	0	3.333333333333333	4.463892865337529	HMGA2
basic amino acid transmembrane transporter activity (GO:0015174)	1/12	0.26206365162305645	1.0	0	0	3.333333333333333	4.463892865337529	SLC38A3
receptor tyrosine kinase binding (GO:0030971)	2/40	0.2642113633345378	1.0	0	0	2.0	2.662011754937148	ANGPT4;ANGPT2
sodium ion transmembrane transporter activity (GO:0015081)	3/72	0.2685696227705788	1.0	0	0	1.6666666666666665	2.1910751599377134	SLC13A4;ATP1A4;SLC4A4
heme binding (GO:0020037)	3/73	0.275367586439176	1.0	0	0	1.643835616438356	2.1199699658854088	CYP2W1;CYP11A1;CYP19A1
hexose transmembrane transporter activity (GO:0015149)	1/13	0.28052310882224873	1.0	0	0	3.076923076923077	3.911074378522308	SLC2A12
glycine binding (GO:0016594)	1/13	0.28052310882224873	1.0	0	0	3.076923076923077	3.911074378522308	GLDC
low-density lipoprotein receptor activity (GO:0005041)	1/13	0.28052310882224873	1.0	0	0	3.076923076923077	3.911074378522308	LRP2
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen (GO:0016709)	2/42	0.2828519333369492	1.0	0	0	1.9047619047619047	2.4053937562173484	CYP11A1;KMO
pyrophosphatase activity (GO:0016462)	2/42	0.2828519333369492	1.0	0	0	1.9047619047619047	2.4053937562173484	PHOSPHO1;ALPL
MAP kinase activity (GO:0004707)	1/14	0.29852170306951037	1.0	0	0	2.8571428571428568	3.4540361191199316	MAPK4
lipoprotein transporter activity (GO:0042954)	1/14	0.29852170306951037	1.0	0	0	2.8571428571428568	3.4540361191199316	LRP2
Rac guanyl-nucleotide exchange factor activity (GO:0030676)	1/14	0.29852170306951037	1.0	0	0	2.8571428571428568	3.4540361191199316	EPS8L1
endopeptidase inhibitor activity (GO:0004866)	4/112	0.30733899532659725	1.0	0	0	1.4285714285714284	1.6854341732739702	SERPINB2;SERPINE2;BIRC7;SERPINB7
interleukin-1 receptor binding (GO:0005149)	1/15	0.3160709178495968	1.0	0	0	2.6666666666666665	3.0714364453326795	IL36RN
lipoprotein particle receptor activity (GO:0030228)	1/15	0.3160709178495968	1.0	0	0	2.6666666666666665	3.0714364453326795	LRP2
purinergic nucleotide receptor activity (GO:0001614)	1/15	0.3160709178495968	1.0	0	0	2.6666666666666665	3.0714364453326795	GPR87
adrenergic receptor binding (GO:0031690)	1/15	0.3160709178495968	1.0	0	0	2.6666666666666665	3.0714364453326795	ADRB1
myosin V binding (GO:0031489)	1/15	0.3160709178495968	1.0	0	0	2.6666666666666665	3.0714364453326795	RAB3B
acetylcholine-gated cation-selective channel activity (GO:0022848)	1/15	0.3160709178495968	1.0	0	0	2.6666666666666665	3.0714364453326795	CHRNE
insulin-like growth factor receptor binding (GO:0005159)	1/15	0.3160709178495968	1.0	0	0	2.6666666666666665	3.0714364453326795	INSL4
peptide N-acetyltransferase activity (GO:0034212)	1/15	0.3160709178495968	1.0	0	0	2.6666666666666665	3.0714364453326795	NAA11
retinoic acid receptor binding (GO:0042974)	1/16	0.33318195100730313	1.0	0	0	2.5	2.7476663470054308	PPARG
cysteine-type endopeptidase activity involved in apoptotic process (GO:0097153)	1/16	0.33318195100730313	1.0	0	0	2.5	2.7476663470054308	CLC
peptidase activator activity (GO:0016504)	1/16	0.33318195100730313	1.0	0	0	2.5	2.7476663470054308	PCOLCE2
sulfuric ester hydrolase activity (GO:0008484)	1/16	0.33318195100730313	1.0	0	0	2.5	2.7476663470054308	ARSI
acid-thiol ligase activity (GO:0016878)	1/16	0.33318195100730313	1.0	0	0	2.5	2.7476663470054308	SLC27A2
adrenergic receptor activity (GO:0004935)	1/16	0.33318195100730313	1.0	0	0	2.5	2.7476663470054308	ADRB1
ionotropic glutamate receptor activity (GO:0004970)	1/16	0.33318195100730313	1.0	0	0	2.5	2.7476663470054308	GRIN2D
RNA polymerase II activating transcription factor binding (GO:0001102)	2/48	0.3383532866029959	1.0	0	0	1.6666666666666665	1.8061078378867632	TBX20;PITX2
transcriptional repressor activity, RNA polymerase II transcription factor binding (GO:0001191)	2/48	0.3383532866029959	1.0	0	0	1.6666666666666665	1.8061078378867632	TFAP2B;ZFP42
protein tyrosine kinase binding (GO:1990782)	2/49	0.3474929610282407	1.0	0	0	1.6326530612244896	1.7257320330061812	ANGPT4;ANGPT2
proton-transporting ATPase activity, rotational mechanism (GO:0046961)	1/17	0.3498657220916832	1.0	0	0	2.352941176470588	2.4710725865370216	ATP6V1C2
organic acid transmembrane transporter activity (GO:0005342)	1/17	0.3498657220916832	1.0	0	0	2.352941176470588	2.4710725865370216	SLC22A11
antiporter activity (GO:0015297)	1/17	0.3498657220916832	1.0	0	0	2.352941176470588	2.4710725865370216	SLC7A5
arachidonic acid monooxygenase activity (GO:0008391)	1/17	0.3498657220916832	1.0	0	0	2.352941176470588	2.4710725865370216	CYP2W1
CoA hydrolase activity (GO:0016289)	1/17	0.3498657220916832	1.0	0	0	2.352941176470588	2.4710725865370216	ACSBG2
DNA binding, bending (GO:0008301)	1/17	0.3498657220916832	1.0	0	0	2.352941176470588	2.4710725865370216	HMGA2
arachidonic acid epoxygenase activity (GO:0008392)	1/17	0.3498657220916832	1.0	0	0	2.352941176470588	2.4710725865370216	CYP2W1
retinol dehydrogenase activity (GO:0004745)	1/17	0.3498657220916832	1.0	0	0	2.352941176470588	2.4710725865370216	DHRS9
aspartic-type peptidase activity (GO:0070001)	1/17	0.3498657220916832	1.0	0	0	2.352941176470588	2.4710725865370216	CTSE
acyl-CoA hydrolase activity (GO:0047617)	1/17	0.3498657220916832	1.0	0	0	2.352941176470588	2.4710725865370216	ACSBG2
voltage-gated potassium channel activity (GO:0005249)	3/86	0.36442414082249097	1.0	0	0	1.3953488372093021	1.4085165595114748	KCNG1;KCNF1;KCNA7
monovalent inorganic cation transmembrane transporter activity (GO:0015077)	1/18	0.3661328787804519	1.0	0	0	2.222222222222222	2.232797677094987	ATP6V1B1
calcium-activated potassium channel activity (GO:0015269)	1/18	0.3661328787804519	1.0	0	0	2.222222222222222	2.232797677094987	KCNN4
semaphorin receptor binding (GO:0030215)	1/18	0.3661328787804519	1.0	0	0	2.222222222222222	2.232797677094987	SEMA7A
nucleoside diphosphate kinase activity (GO:0004550)	1/18	0.3661328787804519	1.0	0	0	2.222222222222222	2.232797677094987	NME2P1
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding (GO:0001205)	1/18	0.3661328787804519	1.0	0	0	2.222222222222222	2.232797677094987	MEOX2
lysine-acetylated histone binding (GO:0070577)	1/18	0.3661328787804519	1.0	0	0	2.222222222222222	2.232797677094987	BRDT
cysteine-type endopeptidase inhibitor activity (GO:0004869)	2/52	0.3746429686919478	1.0	0	0	1.5384615384615385	1.5104335231065098	TFAP2B;BIRC7
hydrogen ion transmembrane transporter activity (GO:0015078)	2/52	0.3746429686919478	1.0	0	0	1.5384615384615385	1.5104335231065098	ATP6V1B1;ATP6V1C2
phosphatidylinositol bisphosphate binding (GO:1902936)	3/88	0.3780598863986252	1.0	0	0	1.3636363636363635	1.3264127267525516	NCF1;ANXA8;SYT7
neuropilin binding (GO:0038191)	1/19	0.3819938041881401	1.0	0	0	2.1052631578947367	2.0260018734944683	SEMA7A
RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding (GO:0001133)	1/19	0.3819938041881401	1.0	0	0	2.1052631578947367	2.0260018734944683	PPARG
acetylation-dependent protein binding (GO:0140033)	1/19	0.3819938041881401	1.0	0	0	2.1052631578947367	2.0260018734944683	BRDT
RNA polymerase II distal enhancer sequence-specific DNA binding (GO:0000980)	2/53	0.38359202335177106	1.0	0	0	1.5094339622641508	1.4463029892393837	ZFP42;MEOX2
organic cation transmembrane transporter activity (GO:0015101)	1/20	0.39745862307532415	1.0	0	0	2.0	1.8453288863961157	SLC44A5
glutamate receptor activity (GO:0008066)	1/20	0.39745862307532415	1.0	0	0	2.0	1.8453288863961157	GRIN2D
ligand-gated calcium channel activity (GO:0099604)	1/20	0.39745862307532415	1.0	0	0	2.0	1.8453288863961157	GRIN2D
glucose transmembrane transporter activity (GO:0005355)	1/20	0.39745862307532415	1.0	0	0	2.0	1.8453288863961157	SLC2A12
protein homodimerization activity (GO:0042803)	18/665	0.39878453658565316	1.0	0	0	1.0827067669172932	0.9953691607290224	TFAP2A;CEBPA;TFAP2B;TENM3;GLDC;SMAGP;TNNC1;APOA2;GRHL1;HLA-G;NR6A1;HAND1;S100P;NECTIN4;NECTIN3;ATF3;MAPK4;ABCG2
metalloexopeptidase activity (GO:0008235)	2/55	0.40132045183103177	1.0	0	0	1.4545454545454544	1.3279927840918175	MMP15;LVRN
SH3 domain binding (GO:0017124)	2/56	0.41009437639646396	1.0	0	0	1.4285714285714284	1.273382799199648	NCF1;ADAM12
growth factor receptor binding (GO:0070851)	3/93	0.41184736294433893	1.0	0	0	1.2903225806451613	1.1446483568607568	IL36RN;AREG;PGF
voltage-gated ion channel activity (GO:0005244)	1/21	0.41253720829731133	1.0	0	0	1.9047619047619047	1.6865311911285241	GRIN2D
sialyltransferase activity (GO:0008373)	1/21	0.41253720829731133	1.0	0	0	1.9047619047619047	1.6865311911285241	ST3GAL4
calcium-dependent cysteine-type endopeptidase activity (GO:0004198)	1/21	0.41253720829731133	1.0	0	0	1.9047619047619047	1.6865311911285241	CAPN6
transcription factor activity, RNA polymerase II core promoter sequence-specific (GO:0000983)	1/21	0.41253720829731133	1.0	0	0	1.9047619047619047	1.6865311911285241	TFAP2B
chemokine receptor activity (GO:0004950)	1/21	0.41253720829731133	1.0	0	0	1.9047619047619047	1.6865311911285241	CCR7
solute:proton symporter activity (GO:0015295)	1/21	0.41253720829731133	1.0	0	0	1.9047619047619047	1.6865311911285241	SLC2A12
hydrogen-exporting ATPase activity (GO:0036442)	1/21	0.41253720829731133	1.0	0	0	1.9047619047619047	1.6865311911285241	ATP6V1C2
aspartic-type endopeptidase activity (GO:0004190)	1/21	0.41253720829731133	1.0	0	0	1.9047619047619047	1.6865311911285241	CTSE
G-protein coupled amine receptor activity (GO:0008227)	2/57	0.41880475936093825	1.0	0	0	1.4035087719298245	1.2215444712550116	CHRM2;ADRB1
lysine N-methyltransferase activity (GO:0016278)	1/22	0.42723918724304594	1.0	0	0	1.8181818181818181	1.5462023001914358	METTL21C
bicarbonate transmembrane transporter activity (GO:0015106)	1/22	0.42723918724304594	1.0	0	0	1.8181818181818181	1.5462023001914358	SLC4A4
actinin binding (GO:0042805)	1/22	0.42723918724304594	1.0	0	0	1.8181818181818181	1.5462023001914358	PPARG
Wnt-activated receptor activity (GO:0042813)	1/22	0.42723918724304594	1.0	0	0	1.8181818181818181	1.5462023001914358	FRZB
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism (GO:0015662)	1/22	0.42723918724304594	1.0	0	0	1.8181818181818181	1.5462023001914358	ATP6V1C2
endoribonuclease activity (GO:0004521)	1/23	0.4415739476417069	1.0	0	0	1.7391304347826086	1.4215822280628116	ENDOU
lipoprotein particle binding (GO:0071813)	1/23	0.4415739476417069	1.0	0	0	1.7391304347826086	1.4215822280628116	APOA2
fibroblast growth factor binding (GO:0017134)	1/23	0.4415739476417069	1.0	0	0	1.7391304347826086	1.4215822280628116	FGFR3
calcium activated cation channel activity (GO:0005227)	1/23	0.4415739476417069	1.0	0	0	1.7391304347826086	1.4215822280628116	KCNN4
phosphatidylinositol-4,5-bisphosphate binding (GO:0005546)	2/61	0.4529669891745948	1.0	0	0	1.3114754098360655	1.0386046265359035	ANXA8;SYT7
transmembrane receptor protein tyrosine kinase activity (GO:0004714)	2/62	0.46132803795917154	1.0	0	0	1.2903225806451613	0.9982527870331739	FLT1;FGFR3
voltage-gated cation channel activity (GO:0022843)	3/101	0.4646041358021239	1.0	0	0	1.188118811881188	0.9107757110849387	KCNG1;KCNF1;KCNA7
miRNA binding (GO:0035198)	1/25	0.4691782022031496	1.0	0	0	1.5999999999999999	1.2108361930392557	TRIM71
ATPase coupled ion transmembrane transporter activity (GO:0042625)	1/25	0.4691782022031496	1.0	0	0	1.5999999999999999	1.2108361930392557	ABCC2
transmembrane receptor protein kinase activity (GO:0019199)	2/63	0.46961389196045544	1.0	0	0	1.2698412698412698	0.9598024487193709	FLT1;FGFR3
mRNA 3'-UTR binding (GO:0003730)	2/64	0.47782308073315993	1.0	0	0	1.25	0.9231434237408449	IGF2BP1;IGF2BP3
epidermal growth factor receptor binding (GO:0005154)	1/26	0.4824653272482855	1.0	0	0	1.5384615384615385	1.1213018790930922	AREG
lipoprotein particle receptor binding (GO:0070325)	1/26	0.4824653272482855	1.0	0	0	1.5384615384615385	1.1213018790930922	APOA2
actin monomer binding (GO:0003785)	1/26	0.4824653272482855	1.0	0	0	1.5384615384615385	1.1213018790930922	MYL4
ATPase activity, coupled to transmembrane movement of ions, rotational mechanism (GO:0044769)	1/26	0.4824653272482855	1.0	0	0	1.5384615384615385	1.1213018790930922	ATP6V1C2
GTPase activity (GO:0003924)	6/223	0.485658240141715	1.0	0	0	1.0762331838565022	0.7773095376155262	GNGT1;RAB3B;NLRP10;RASA1;RHOV;RHOBTB1
mitogen-activated protein kinase kinase binding (GO:0031434)	2/66	0.49400617659427287	1.0	0	0	1.2121212121212122	0.8547966771455834	FLT1;FGFR3
enhancer binding (GO:0035326)	1/27	0.49542050679657673	1.0	0	0	1.4814814814814814	1.0405161012766946	TFAP2B
RNA polymerase II transcription corepressor activity (GO:0001106)	1/27	0.49542050679657673	1.0	0	0	1.4814814814814814	1.0405161012766946	TFAP2B
secondary active transmembrane transporter activity (GO:0015291)	2/67	0.5019777233846834	1.0	0	0	1.1940298507462686	0.8229248191077754	SLC7A5;SLC22A11
cation channel activity (GO:0005261)	4/147	0.5029167460190818	1.0	0	0	1.0884353741496597	0.748114979541874	KCNG1;KCNF1;TRPV6;KCNN4
substrate-specific channel activity (GO:0022838)	1/28	0.5080520173426427	1.0	0	0	1.4285714285714284	0.9673877718600257	TRPV6
phospholipase C activity (GO:0004629)	1/28	0.5080520173426427	1.0	0	0	1.4285714285714284	0.9673877718600257	NOTUM
protein tyrosine kinase activity (GO:0004713)	4/148	0.5082257213520626	1.0	0	0	1.0810810810810811	0.7317076721300466	FLT1;HGF;CSF2RB;FGFR3
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)	2/69	0.5176757123539347	1.0	0	0	1.1594202898550725	0.7633695892092621	HGF;FGFR3
inorganic anion exchanger activity (GO:0005452)	1/29	0.5203679297086519	1.0	0	0	1.379310344827586	0.9009919454829998	SLC22A11
kinesin binding (GO:0019894)	1/29	0.5203679297086519	1.0	0	0	1.379310344827586	0.9009919454829998	FAM83D
dicarboxylic acid transmembrane transporter activity (GO:0005310)	1/29	0.5203679297086519	1.0	0	0	1.379310344827586	0.9009919454829998	ABCC2
RNA polymerase II repressing transcription factor binding (GO:0001103)	1/29	0.5203679297086519	1.0	0	0	1.379310344827586	0.9009919454829998	ZFP42
endopeptidase activity (GO:0004175)	9/355	0.5302762597473659	1.0	0	0	1.0140845070422535	0.6432917713661455	MMP12;COLEC10;MMP15;HTRA4;PRSS8;RHBDL3;CTSE;PRSS12;PAPPA2
alpha-actinin binding (GO:0051393)	1/30	0.5323761135569396	1.0	0	0	1.3333333333333333	0.8405400787509358	PPARG
excitatory extracellular ligand-gated ion channel activity (GO:0005231)	1/30	0.5323761135569396	1.0	0	0	1.3333333333333333	0.8405400787509358	CHRNE
nucleosomal DNA binding (GO:0031492)	1/30	0.5323761135569396	1.0	0	0	1.3333333333333333	0.8405400787509358	HMGA2
phosphotyrosine residue binding (GO:0001784)	1/30	0.5323761135569396	1.0	0	0	1.3333333333333333	0.8405400787509358	RASA1
organic anion transmembrane transporter activity (GO:0008514)	2/71	0.533041249161984	1.0	0	0	1.1267605633802817	0.7089086955075764	ABCC2;SLC22A11
phosphatidylinositol bisphosphate kinase activity (GO:0052813)	2/72	0.5405975770602098	1.0	0	0	1.111111111111111	0.6834223634393684	HGF;FGFR3
nucleobase-containing compound kinase activity (GO:0019205)	1/31	0.5440842429149877	1.0	0	0	1.2903225806451613	0.7853563687947012	NME2P1
MHC protein binding (GO:0042287)	1/31	0.5440842429149877	1.0	0	0	1.2903225806451613	0.7853563687947012	COL2A1
protein serine/threonine kinase inhibitor activity (GO:0030291)	1/31	0.5440842429149877	1.0	0	0	1.2903225806451613	0.7853563687947012	PKIB
NADP binding (GO:0050661)	1/31	0.5440842429149877	1.0	0	0	1.2903225806451613	0.7853563687947012	HSD17B1
protein serine/threonine kinase activator activity (GO:0043539)	1/32	0.5554998006860319	1.0	0	0	1.25	0.7348587858794243	TCL1B
ligand-gated channel activity (GO:0022834)	1/32	0.5554998006860319	1.0	0	0	1.25	0.7348587858794243	CHRNE
monocarboxylic acid transmembrane transporter activity (GO:0008028)	1/33	0.5666300836000462	1.0	0	0	1.2121212121212122	0.6885437552033686	SLC38A3
phosphatidylinositol-3,4,5-trisphosphate binding (GO:0005547)	1/33	0.5666300836000462	1.0	0	0	1.2121212121212122	0.6885437552033686	ANXA8
hydrolase activity, hydrolyzing O-glycosyl compounds (GO:0004553)	1/33	0.5666300836000462	1.0	0	0	1.2121212121212122	0.6885437552033686	ACER2
phosphatidylinositol 3-kinase activity (GO:0035004)	2/77	0.5770948361053473	1.0	0	0	1.0389610389610389	0.571167444479923	HGF;FGFR3
thiol-dependent ubiquitin-specific protease activity (GO:0004843)	2/77	0.5770948361053473	1.0	0	0	1.0389610389610389	0.571167444479923	USP27X;USP9Y
phosphoric diester hydrolase activity (GO:0008081)	1/34	0.5774822066735724	1.0	0	0	1.176470588235294	0.6459737035478923	NOTUM
transmitter-gated ion channel activity (GO:0022824)	1/34	0.5774822066735724	1.0	0	0	1.176470588235294	0.6459737035478923	GRIN2D
sodium-independent organic anion transmembrane transporter activity (GO:0015347)	1/34	0.5774822066735724	1.0	0	0	1.176470588235294	0.6459737035478923	SLC22A11
ion channel inhibitor activity (GO:0008200)	1/34	0.5774822066735724	1.0	0	0	1.176470588235294	0.6459737035478923	RASA1
syntaxin binding (GO:0019905)	2/78	0.5841351052931448	1.0	0	0	1.0256410256410255	0.5514081827999194	SYT8;SYT7
protein phosphorylated amino acid binding (GO:0045309)	1/35	0.5880631079793313	1.0	0	0	1.1428571428571428	0.6067668689681428	RASA1
MAP kinase kinase kinase activity (GO:0004709)	2/79	0.591088531821221	1.0	0	0	1.0126582278481011	0.5324450357053537	FLT1;FGFR3
neuropeptide receptor activity (GO:0008188)	1/36	0.5983795526602211	1.0	0	0	1.111111111111111	0.5705889143615132	KISS1R
manganese ion binding (GO:0030145)	1/36	0.5983795526602211	1.0	0	0	1.111111111111111	0.5705889143615132	ENDOU
kinase binding (GO:0019900)	10/419	0.6039665816223428	1.0	0	0	0.954653937947494	0.48137127543467917	CEBPA;TCL1B;MYCN;SPDYC;OSR1;RHOV;FAM83D;SRCIN1;RHOBTB1;MAPK4
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315)	1/37	0.6084381377362886	1.0	0	0	1.0810810810810811	0.5371459840670496	CHRNE
peptidase inhibitor activity (GO:0030414)	1/37	0.6084381377362886	1.0	0	0	1.0810810810810811	0.5371459840670496	GPC3
cysteine-type endopeptidase activity (GO:0004197)	2/82	0.611427375574375	1.0	0	0	0.975609756097561	0.4799600929754372	CAPN6;CLC
CCR chemokine receptor binding (GO:0048020)	1/39	0.6278072988155387	1.0	0	0	1.0256410256410255	0.4774584703811021	CCRL2
amino acid binding (GO:0016597)	1/40	0.6371302636481142	1.0	0	0	1.0	0.4507811487933908	GLDC
sulfotransferase activity (GO:0008146)	1/40	0.6371302636481142	1.0	0	0	1.0	0.4507811487933908	HS3ST3A1
sodium channel activity (GO:0005272)	1/41	0.6462201541186453	1.0	0	0	0.975609756097561	0.42596589015410175	SCNN1B
protein kinase C binding (GO:0005080)	1/41	0.6462201541186453	1.0	0	0	0.975609756097561	0.42596589015410175	DACT2
protein methyltransferase activity (GO:0008276)	1/42	0.6550827855909762	1.0	0	0	0.9523809523809523	0.4028511058268805	METTL21C
phosphotransferase activity, phosphate group as acceptor (GO:0016776)	1/42	0.6550827855909762	1.0	0	0	0.9523809523809523	0.4028511058268805	NME2P1
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616)	2/89	0.6558581466108996	1.0	0	0	0.898876404494382	0.37915573334263386	DHRS9;PHGDH
protein heterodimerization activity (GO:0046982)	6/266	0.6568563767589388	1.0	0	0	0.9022556390977443	0.3792089224274068	TFAP2B;TENM3;APOA2;PPARG;ADRB1;ATF3
phosphoprotein phosphatase activity (GO:0004721)	3/137	0.6694281778392484	1.0	0	0	0.8759124087591241	0.35153115058518086	DUSP5;DUSP9;DUSP13
lipase activity (GO:0016298)	1/44	0.6721488131969349	1.0	0	0	0.9090909090909091	0.3611595588775441	GOLT1A
potassium channel regulator activity (GO:0015459)	1/44	0.6721488131969349	1.0	0	0	0.9090909090909091	0.3611595588775441	RASA1
1-phosphatidylinositol-3-kinase activity (GO:0016303)	1/44	0.6721488131969349	1.0	0	0	0.9090909090909091	0.3611595588775441	FGFR3
cholesterol binding (GO:0015485)	1/44	0.6721488131969349	1.0	0	0	0.9090909090909091	0.3611595588775441	APOA2
thiol-dependent ubiquitinyl hydrolase activity (GO:0036459)	2/93	0.6793739096257446	1.0	0	0	0.8602150537634409	0.33254505468787643	USP27X;USP9Y
ion channel activity (GO:0005216)	2/94	0.6850442087819228	1.0	0	0	0.8510638297872339	0.3219335356890655	TRPV6;CHRNE
single-stranded RNA binding (GO:0003727)	1/46	0.688372038071095	1.0	0	0	0.8695652173913043	0.32471811668930733	L1TD1
integrin binding (GO:0005178)	2/95	0.6906320962251579	1.0	0	0	0.8421052631578947	0.31170359515928925	SEMA7A;EGFL6
damaged DNA binding (GO:0003684)	1/47	0.69618066242957	1.0	0	0	0.8510638297872339	0.30820942968045956	TP63
myosin binding (GO:0017022)	1/47	0.69618066242957	1.0	0	0	0.8510638297872339	0.30820942968045956	RAB3B
protein kinase binding (GO:0019901)	11/496	0.6991718180335578	1.0	0	0	0.8870967741935484	0.31745535291622523	TCL1B;FLT1;SPDYC;OSR1;DACT2;RHOV;FAM83D;SRCIN1;FGFR3;RHOBTB1;MAPK4
protein-lysine N-methyltransferase activity (GO:0016279)	1/48	0.7037940023867141	1.0	0	0	0.8333333333333333	0.29272464657414204	METTL21C
cation transmembrane transporter activity (GO:0008324)	2/98	0.7069070769803031	1.0	0	0	0.8163265306122448	0.283147799645867	CHRNE;SLC38A3
flavin adenine dinucleotide binding (GO:0050660)	1/49	0.7112169323217401	1.0	0	0	0.8163265306122448	0.27818594854238055	KMO
inorganic anion transmembrane transporter activity (GO:0015103)	1/49	0.7112169323217401	1.0	0	0	0.8163265306122448	0.27818594854238055	SLC22A11
sterol binding (GO:0032934)	1/49	0.7112169323217401	1.0	0	0	0.8163265306122448	0.27818594854238055	APOA2
double-stranded DNA binding (GO:0003690)	2/100	0.7173559974425507	1.0	0	0	0.7999999999999999	0.2657464415359102	PPARG;TP63
ribonuclease activity (GO:0004540)	1/50	0.7184542048692922	1.0	0	0	0.7999999999999999	0.26452265010260456	ENDOU
chemokine receptor binding (GO:0042379)	1/50	0.7184542048692922	1.0	0	0	0.7999999999999999	0.26452265010260456	CCRL2
microtubule binding (GO:0008017)	4/196	0.7255223635638707	1.0	0	0	0.8163265306122448	0.2619292915074513	CAPN6;FAM83D;CCSAP;S100A9
serine-type endopeptidase activity (GO:0004252)	4/197	0.7291779769722512	1.0	0	0	0.8121827411167512	0.256517716355367	MMP12;COLEC10;RHBDL3;PRSS12
phosphatidylinositol kinase activity (GO:0052742)	1/52	0.7323902008010184	1.0	0	0	0.7692307692307693	0.23957065064915506	FGFR3
GDP binding (GO:0019003)	1/52	0.7323902008010184	1.0	0	0	0.7692307692307693	0.23957065064915506	RAB3B
methylation-dependent protein binding (GO:0140034)	1/53	0.7390978494043314	1.0	0	0	0.7547169811320754	0.22816978033568033	DPPA3
extracellular ligand-gated ion channel activity (GO:0005230)	1/53	0.7390978494043314	1.0	0	0	0.7547169811320754	0.22816978033568033	CHRNE
repressing transcription factor binding (GO:0070491)	1/54	0.7456376971972923	1.0	0	0	0.7407407407407407	0.21741885729120122	ZFP42
iron ion binding (GO:0005506)	1/55	0.752013933732217	1.0	0	0	0.7272727272727272	0.20727303731253116	FDX1
protein kinase activator activity (GO:0030295)	1/56	0.758230644178816	1.0	0	0	0.7142857142857142	0.19769118550302078	TCL1B
methylated histone binding (GO:0035064)	1/56	0.758230644178816	1.0	0	0	0.7142857142857142	0.19769118550302078	DPPA3
chloride transmembrane transporter activity (GO:0015108)	1/57	0.7642918118808011	1.0	0	0	0.7017543859649122	0.18863551580170362	CLIC3
nuclear hormone receptor binding (GO:0035257)	1/57	0.7642918118808011	1.0	0	0	0.7017543859649122	0.18863551580170362	LRP2
transferase activity, transferring acyl groups other than amino-acyl groups (GO:0016747)	1/57	0.7642918118808011	1.0	0	0	0.7017543859649122	0.18863551580170362	PORCN
purine ribonucleoside binding (GO:0032550)	3/160	0.7667655416368673	1.0	0	0	0.7499999999999999	0.1991806550221081	RAB3B;RHOV;RHOBTB1
Rho guanyl-nucleotide exchange factor activity (GO:0005089)	1/60	0.7815804178020295	1.0	0	0	0.6666666666666666	0.1642914883710904	EPS8L1
chloride channel activity (GO:0005254)	1/62	0.7923971144117075	1.0	0	0	0.6451612903225806	0.15012426177080712	CLIC3
PDZ domain binding (GO:0030165)	1/63	0.7976032864598676	1.0	0	0	0.6349206349206349	0.143583453909114	ADRB1
guanyl ribonucleotide binding (GO:0032561)	3/171	0.8043668655403171	1.0	0	0	0.7017543859649122	0.15277179891457604	RAB3B;RHOV;RHOBTB1
ligand-dependent nuclear receptor transcription coactivator activity (GO:0030374)	1/66	0.8124529129968876	1.0	0	0	0.6060606060606061	0.12587716344981695	PPARG
cysteine-type peptidase activity (GO:0008234)	1/66	0.8124529129968876	1.0	0	0	0.6060606060606061	0.12587716344981695	USP9Y
anion channel activity (GO:0005253)	1/67	0.8171570734698834	1.0	0	0	0.5970149253731343	0.12055160967876961	CLIC3
RNA helicase activity (GO:0003724)	1/68	0.8217434703815468	1.0	0	0	0.588235294117647	0.11548647791811906	DQX1
ATP-dependent RNA helicase activity (GO:0004004)	1/68	0.8217434703815468	1.0	0	0	0.588235294117647	0.11548647791811906	DQX1
RNA-dependent ATPase activity (GO:0008186)	1/69	0.8262150460248844	1.0	0	0	0.5797101449275363	0.11066677859030163	DQX1
ligand-gated ion channel activity (GO:0015276)	1/69	0.8262150460248844	1.0	0	0	0.5797101449275363	0.11066677859030163	CHRNE
Rab GTPase binding (GO:0017137)	2/131	0.842793086389536	1.0	0	0	0.6106870229007633	0.10444812227821715	TBC1D26;SLC6A4
endonuclease activity (GO:0004519)	1/74	0.8469485510129866	1.0	0	0	0.5405405405405406	0.08979206961117422	ENDOU
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (GO:0016811)	1/76	0.8545332771182171	1.0	0	0	0.5263157894736842	0.08273675463408255	ACER2
GTPase binding (GO:0051020)	1/77	0.8581837738781999	1.0	0	0	0.5194805194805194	0.07944779935587648	RASA1
calcium ion transmembrane transporter activity (GO:0015085)	1/78	0.8617428383211508	1.0	0	0	0.5128205128205128	0.07630686371389282	TRPV6
protein transporter activity (GO:0008565)	1/81	0.8718940108877108	1.0	0	0	0.49382716049382713	0.06769748622604009	LRP2
phosphatidylinositol phosphate binding (GO:1901981)	1/82	0.8751096392159449	1.0	0	0	0.4878048780487805	0.0650761456161355	ANXA8
immunoglobulin receptor binding (GO:0034987)	1/82	0.8751096392159449	1.0	0	0	0.4878048780487805	0.0650761456161355	IGHE
transition metal ion binding (GO:0046914)	7/400	0.8755459963750372	1.0	0	0	0.7000000000000001	0.09303531396026103	MMP12;ENDOU;LVRN;FDX1;PPARG;S100A9;PAPPA2
zinc ion binding (GO:0008270)	5/303	0.8783711885454706	1.0	0	0	0.66006600660066	0.08560132586816255	MMP12;LVRN;PPARG;S100A9;PAPPA2
tubulin binding (GO:0015631)	4/256	0.8857490309259219	1.0	0	0	0.625	0.0758260183180831	CAPN6;FAM83D;CCSAP;S100A9
ATP-dependent helicase activity (GO:0008026)	1/86	0.8871864408298141	1.0	0	0	0.46511627906976744	0.055674477287034875	DQX1
histone deacetylase binding (GO:0042826)	1/86	0.8871864408298141	1.0	0	0	0.46511627906976744	0.055674477287034875	GCM1
GTP binding (GO:0005525)	2/148	0.8878025668300037	1.0	0	0	0.5405405405405406	0.06432751100587912	RHOV;RHOBTB1
transcription corepressor activity (GO:0003714)	3/204	0.8878494294384736	1.0	0	0	0.588235294117647	0.06997241871193771	TFAP2B;HAND1;ATF3
protein phosphatase binding (GO:0019903)	1/93	0.9055837893531324	1.0	0	0	0.43010752688172044	0.04265611705062928	KCNN4
calcium channel activity (GO:0005262)	1/94	0.9079551737327357	1.0	0	0	0.42553191489361697	0.041089476483082504	TRPV6
nucleoside-triphosphatase activity (GO:0017111)	7/425	0.9097869848534588	1.0	0	0	0.6588235294117647	0.062288331873903785	RAB3B;GNGT1;NLRP10;RASA1;FIGN;RHOV;RHOBTB1
phosphatidylinositol binding (GO:0035091)	1/101	0.9229711233572102	1.0	0	0	0.396039603960396	0.03174547746753108	NCF1
phosphatase binding (GO:0019902)	1/103	0.9267934783334831	1.0	0	0	0.38834951456310673	0.029524086681869306	KCNN4
mRNA binding (GO:0003729)	2/180	0.9418572221921205	1.0	0	0	0.4444444444444444	0.02662292652962605	IGF2BP1;IGF2BP3
protein kinase activity (GO:0004672)	8/514	0.9460267947355794	1.0	0	0	0.622568093385214	0.03454280845857378	FLT1;NRK;HGF;OSR1;CSF2RB;PRKCZ;FGFR3;MAPK4
Ras GTPase binding (GO:0017016)	2/185	0.9476493218443465	1.0	0	0	0.43243243243243246	0.023252220033882765	TBC1D26;SLC6A4
protease binding (GO:0002020)	1/119	0.9512875582335184	1.0	0	0	0.3361344537815126	0.016786180690548515	CARD17
protein serine/threonine kinase activity (GO:0004674)	5/369	0.9555052015380445	1.0	0	0	0.5420054200542005	0.024669415463458463	NRK;OSR1;HMGA2;PRKCZ;MAPK4
cadherin binding (GO:0045296)	4/314	0.9561860368014349	1.0	0	0	0.5095541401273885	0.02282944494166437	EPS8L1;S100P;BZW2;MB21D2
magnesium ion binding (GO:0000287)	1/128	0.9612683274118383	1.0	0	0	0.3125	0.012344278786206636	S100P
ATPase activity (GO:0016887)	2/204	0.9650279113932755	1.0	0	0	0.39215686274509803	0.013960099740326437	NLRP10;FIGN
GTPase activator activity (GO:0005096)	2/250	0.9871639719742186	1.0	0	0	0.32	0.004134118931474389	RASA1;TBC1D26
ubiquitin-like protein ligase activity (GO:0061659)	1/187	0.9914051753183738	1.0	0	0	0.213903743315508	0.0018464113790567032	RNF128
ubiquitin protein ligase activity (GO:0061630)	1/193	0.9926269421435171	1.0	0	0	0.20725388601036268	0.0015337561026800678	RNF128
GTPase regulator activity (GO:0030695)	2/276	0.9928093521281631	1.0	0	0	0.2898550724637681	0.0020917754157364827	RASA1;TBC1D26
ubiquitin-protein transferase activity (GO:0004842)	4/418	0.9934855770595931	1.0	0	0	0.3827751196172248	0.0025017165161792167	TRIM71;RNF128;NEURL1;BIRC7
kinase activity (GO:0016301)	2/281	0.9935734401139033	1.0	0	0	0.2846975088967971	0.001835529999848937	CKMT1A;PRKCZ
purine ribonucleoside triphosphate binding (GO:0035639)	3/397	0.9974603388070725	1.0	0	0	0.30226700251889166	7.686322225709107E-4	RHOV;ABCA12;RHOBTB1
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	1/255	0.99849068052411	1.0	0	0	0.1568627450980392	2.369348464201425E-4	PRKCZ
ATP binding (GO:0005524)	1/256	0.9985288261285339	1.0	0	0	0.15625	2.3004017348410727E-4	ABCA12
adenyl ribonucleotide binding (GO:0032559)	1/280	0.9992040150279616	1.0	0	0	0.14285714285714285	1.137574194695098E-4	ABCA12
olfactory receptor activity (GO:0004984)	1/312	0.999648547552885	1.0	0	0	0.1282051282051282	4.506592576928508E-5	OR2B6
RNA binding (GO:0003723)	9/1388	0.9999950353739272	1.0	0	0	0.25936599423631124	1.287658373757332E-6	TRIM71;ENDOU;LIN28B;DQX1;PEG10;IGF2BP1;L1TD1;IGF2BP3;MBNL3
